GAME-CHANGING BREAKTHROUGHS THAT DELIVER
photo: Kento Okada
Technology—
Patients need cell therapy that allows effective long-term treatment and doesn’t impede their daily living.
Persista Bio™ addresses the challenges of stem cell therapies head on.
THE PERSISTA BIO™ SOLUTION:
Encapsulation—protects the cells from the immune system, while
allowing therapeutic interaction with the body
Implanted Oxygenation—results in healthier cells and a longer lasting treatment with fully implantable technology that cuts infection risk and doesn’t impede lifestyle
Higher Density of Cells—uses a smaller, patient-friendly cell capsule to provide a therapeutic cell dose
Biocompatible, Soft and Flexible Design—reduces dense scar tissue (fibrosis) around the cell capsule, enhancing effectiveness and lifespan
Result: healthier cells, longer lasting implant, no repercussions from anti-rejection drugs
PERSISTA BIO O2LINE™ SYSTEM INCLUDES:
- a unique anti-fibrotic cell capsule which prevents immune rejection of the implant and enables quick diffusion of the therapeutic, and
- an in-situ oxygen generator to support the densely packed, macroencapsulated cells.
In preclinical testing, the O2line™ prototype has cured diabetic rats, normalizing their blood glucose for 90 days
TYPE 1 DIABETES IS THE FIRST PERSISTA BIO CELL THERAPY APPLICATION
PERSISTA BIO™ O2LINE™ OXYGENATED ENCAPSULATION SYSTEM for insulin-secreting stem cells
- First system to fully support viability and function of densely packed, insulin-secreting cells.
- Self-Regulating—The pancreatic stem cells respond to and automatically regulate the level of glucose in the body—no estimates, calculations, daily needle pricks or sensors
- The O2Line™ System combines the implantable oxygenation technology
licensed from Giner, Inc. and the macroencapsulation technologies
licensed from Cornell. - Implanted, fast-response, high cell capacity, and oxygenated encapsulation device that avoids immune system rejection. This medical device system is realistic, practical and effective.
- Translatable to other emerging implantable cell therapies for metabolic disorders (obesity, enzyme deficiencies, etc.) and other conditions
We mimic the natural action of a pancreas. The encapsulated pancreatic cells have access to the glucose in the body, sense its level, and automatically secrete the insulin needed to regulate blood sugar.
A curative treatment for T1 diabetes that lasts for years!
The Persista Bio O2Line™ oxygenation technology enables therapeutic cells to live
(1-5% O2 inside body)
red = dead cells
No Oxygenation
green = living cells
O2Line™ Oxygenation
The image at left shows therapeutic cells without additional oxygenation. The image at right shows cells living due to Persista implanted oxygenation.
iEOG = Implantable eletrochemical oxygen generator
Next steps: large animal studies, product development and partnering with stem cell providers.
Persista Bio technology enables the dream of biotherapeutics with a practical delivery method that allows carefree living and facilitates optimal health.
Islet image: X. Wang, et. al, Sci. Transl. Med. 2021, 13, eabb4601. (Minglin Ma lab)